Mollie and James are together and raising a family, which now consists of an older Mikey and his baby sister, Julie. Tension between the siblings arises, and as well with Mollie and James when Mollie's brother Stuart moves in. Mikey is also learning how to use the toilet for the first time.
Unfortunately the movie Look Who's Talking Too is not yet available on Disney Plus.
| Editing | Debra Chiate | Editor |
| Production | Jonathan D. Krane | Producer |
| Directing | Amy Heckerling | Director |
| Camera | Thomas Del Ruth | Director of Photography |
| Writing | Amy Heckerling | Characters |
| Writing | Neal Israel | Writer |
| Sound | David Kitay | Original Music Composer |
| Writing | Amy Heckerling | Writer |
| Crew | Allen Benjamin | Special Effects Coordinator |
| Art | Barry W. Brolly | Set Decoration |
| Art | Richard Wilcox | Art Direction |
| Art | Reuben Freed | Production Design |
| Costume & Make-Up | Molly Maginnis | Costume Design |
| Crew | Rick Avery | Stunt Coordinator |
| Directing | Judy Slattery | Third Assistant Director |
