The accidental mix-up of four identical plaid overnight bags leads to a series of increasingly wild and wacky situations.
Unfortunately the movie What's Up, Doc? is not yet available on Disney Plus.
| Directing | Peter Bogdanovich | Director |
| Writing | Buck Henry | Screenplay |
| Writing | David Newman | Screenplay |
| Writing | Robert Benton | Screenplay |
| Production | Peter Bogdanovich | Producer |
| Editing | Verna Fields | Editor |
| Production | Nessa Hyams | Casting |
| Art | Polly Platt | Production Design |
| Art | John P. Austin | Set Decoration |
| Costume & Make-Up | Ray Phelps | Costume Supervisor |
| Costume & Make-Up | Nancy McArdle | Costume Supervisor |
| Art | Robey Cooper | Property Master |
| Directing | Hazel W. Hall | Script Supervisor |
| Sound | Richard Raguse | Boom Operator |
| Editing | William Neel | Assistant Editor |
| Directing | Doug Morrison | Second Assistant Director |
| Directing | Jerry Ballew | Second Assistant Director |
| Camera | Bobby Byrne | Camera Operator |
| Lighting | Richmond L. Aguilar | Gaffer |
| Camera | Leonard Lookabaugh | Dolly Grip |
| Camera | George Hill | Key Grip |
| Camera | Dick Colean | Assistant Camera |
| Camera | Robert L. Guthrie | Assistant Camera |
| Crew | Paul Baxley | Stunt Coordinator |
| Crew | R.A. MacDonald | Special Effects |
| Art | Norman Hawkins | Construction Coordinator |
| Production | Harry Zubrinsky | Location Manager |
| Production | Paul Lewis | Associate Producer |
| Directing | Ray Gosnell Jr. | Assistant Director |
| Sound | Artie Butler | Music Arranger |
| Sound | Artie Butler | Conductor |
| Crew | Joe Amsler | Stunts |
| Crew | Craig R. Baxley | Stunts |
| Crew | Paul Baxley | Stunts |
| Crew | Jerry Brutsche | Stunts |
| Crew | Richard E. Butler | Stunts |
| Crew | Ted Duncan | Stunts |
| Crew | Patty Elder | Stunts |
| Crew | Donna Garrett | Stunts |
| Crew | Ted Grossman | Stunts |
| Crew | Bob Harris | Stunts |
| Crew | Bill Hickman | Stunts |
| Crew | Loren Janes | Stunts |
| Crew | Dean Jeffries | Stunts |
| Crew | John Moio | Stunts |
| Crew | Victor Paul | Stunts |
| Crew | Joe Pronto | Stunts |
| Crew | Glenn Randall Jr. | Stunts |
| Crew | Ernest Robinson | Stunts |
| Crew | George Robotham | Stunts |
| Crew | Wally Rose | Stunts |
| Crew | Alex Sharp | Stunts |
| Crew | Paul Stader | Stunts |
| Crew | Fred Stromsoe | Stunts |
| Crew | Jerry Summers | Stunts |
| Crew | Morton C. Thompson | Stunts |
| Crew | Jack Verbois | Stunts |
| Crew | Bud Walls | Stunts |
| Crew | Marvin Walters | Stunts |
| Crew | Richard Washington | Stunts |
| Sound | Artie Butler | Music |
| Writing | Peter Bogdanovich | Story |
| Art | Herman A. Blumenthal | Art Direction |
| Costume & Make-Up | Don L. Cash | Makeup Artist |
| Costume & Make-Up | Lynda Gurasich | Hairstylist |
| Costume & Make-Up | Fred Williams | Makeup Artist |
| Production | Fred Ahern | Unit Production Manager |
| Sound | Les Fresholtz | Sound |
| Camera | László Kovács | Director of Photography |
