Dr. Frankenstein's Granddaughter Maria, and her brother assistant Rudolph, moved to the old west because the lightning storms there are more frequent and intense, which allows them to work on the experiments of their grandfather. But the experiments are failing and Rudolph's been secretly killing the corpses afterwards. Meanwhile, the Lopez family leaves the town because of the evil going on there
Unfortunately the movie Jesse James Meets Frankenstein's Daughter is not yet available on Disney Plus.
| Directing | William Beaudine | Director |
| Writing | Carl K. Hittleman | Screenplay |
| Production | Carroll Case | Producer |
| Camera | Lothrop B. Worth | Director of Photography |
| Art | Harry Reif | Set Decoration |
| Costume & Make-Up | Charles Arrico | Costume Design |
| Costume & Make-Up | Reneé Dietrich | Costume Design |
| Costume & Make-Up | Jeanne Bodel | Hairstylist |
| Costume & Make-Up | Ted Coodley | Makeup Artist |
| Writing | Carl K. Hittleman | Original Story |
| Art | Paul Sylos | Art Direction |
| Directing | Max Stein | Assistant Director |
| Sound | Raoul Kraushaar | Original Music Composer |
