In Guesta Verde University, the deranged Professor Curien is trying to bring back the dead, killing students for the experiment. There is an outbreak of zombies in the campus, and the government sends a NSA medical research team, formed by Dr. Alexandra Morgan a.k.a. Nightingale and lieutenant Ellis, with a special force leaded by lieutenant Dalton, trying to get the zero sample from the first generation zombie. The team has a very short time to accomplish their mission and leave the place before missiles are sent to destroy the area. However, the place is crowded of hyper sapiens and the group has to fight to survive.
Unfortunately the movie House of the Dead 2 is not yet available on Disney Plus.
| Writing | Peter Scheerer | Writer |
| Writing | Michael Roesch | Writer |
| Writing | Mark A. Altman | Writer |
| Directing | Michael Hurst | Director |
| Crew | Erik Betts | Stunts |
| Crew | Nicole Basanda | Stunts |
| Crew | Allison Caetano | Stunts |
| Crew | Vanessa Vander Pluym | Stunts |
| Crew | Tsuyoshi Abe | Stunts |
| Crew | Nils Allen Stewart | Stunts |
| Crew | Ronn Surels | Stunts |
| Crew | Yoshio Iizuka | Stunts |
| Production | Chuck Speed | Co-Producer |
| Production | Jason Constantine | Executive Producer |
| Editing | Joseph Gutowski | Editor |
| Costume & Make-Up | Nanci Cascio | Key Hair Stylist |
| Crew | David Mattey | Stunts |
| Crew | Danny Ray Cook | Stunts |
| Sound | Jesse Pomeroy | Supervising Sound Editor |
| Production | Mindy Bazar | Casting |
| Costume & Make-Up | Jennifer L. Soulages | Costume Design |
| Production | Peter Block | Executive Producer |
| Costume & Make-Up | Tatiana Thorpe | Makeup Department Head |
| Costume & Make-Up | Verina Schafer | Key Hair Stylist |
| Crew | Crystal Santos | Stunts |
| Art | Denise Pizzini | Production Design |
| Lighting | Stephen Crawford | Gaffer |
| Camera | Jeffrey D. Smith | Second Unit Director of Photography |
| Art | Dorit Hurst | Set Decoration |
| Costume & Make-Up | Sallie Nicole Ciganovich | Key Hair Stylist |
| Visual Effects | Stephen Lebed | Visual Effects Supervisor |
| Production | Daniel S. Kletzky | Co-Executive Producer |
| Camera | Raymond Stella | Director of Photography |
| Sound | Joe Kraemer | Music |
| Camera | Mark J. Coyne | Camera Operator |
| Crew | Tina Mahler | Stunts |
| Crew | Danny Wayne | Stunt Coordinator |
| Art | Robert W. Joseph | Art Direction |
| Directing | Jim Whitworth | First Assistant Director |
| Directing | Andy Hurst | Second Unit Director |
| Crew | Christie Sanders | Stunts |
| Costume & Make-Up | Soo-Jin Yoon | Hair Department Head |
| Sound | Andy Hay | Sound Re-Recording Mixer |
| Production | Mark Gottwald | Producer |
| Production | Mark A. Altman | Producer |
| Crew | Lauren Mary Kim | Stunts |
| Art | Kevin Greutert | Opening Title Sequence |
