The Egyptian Queen Cleopatra bets against the Roman Emperor, Julius Caesar, that her people are still great, even if the times of the Pharaohs has long passed. She vows (against all logic) to build a new palace for Caesar within three months. Since all her architects are either busy otherwise or too conservative in style, this ambivalent honor falls to Edifis. He is to build the palace and be covered in gold or, if not, his fate is to be eaten by crocodiles. Edifis calls upon an old friend to help him out: The fabulous Druid Getafix from Gaul, who brews a fantastic potion that gives supernatural strength. In order to help and protect the old Druid, Asterix and Obelix accompany him on his journey to Egypt. When Julius Caesar gets wind of the project succeeding, he has the building site attacked by his troops in order to win the bet and not lose face. But just like the local pirates, he hasn't counted on Asterix and Obelix.
Unfortunately the movie Asterix & Obelix: Mission Cleopatra is not yet available on Disney Plus.
| Writing | Alain Chabat | Screenplay |
| Directing | Alain Chabat | Director |
| Writing | René Goscinny | Author |
| Production | Claude Berri | Producer |
| Production | Luce Nordmann | Casting |
| Production | Laurent Soulet | Casting |
| Costume & Make-Up | Tanino Liberatore | Costume Design |
| Production | Mustapha Fathi | Casting |
| Art | Laurent Ott | Art Direction |
| Art | Françoise Doré | Set Decoration |
| Production | Noureddine Aberdine | Casting |
| Production | Jeanne Biras | Casting |
| Costume & Make-Up | Florence Sadaune | Costume Design |
| Art | Hoang Thanh At | Production Design |
| Art | Hoang Thanh At | Set Decoration |
| Costume & Make-Up | Sylvie Ferry | Special Effects Makeup Artist |
| Sound | Thierry Lebon | Sound Re-Recording Mixer |
| Costume & Make-Up | Khalid Alami | Key Makeup Artist |
| Costume & Make-Up | Christophe Danchaud | Key Makeup Artist |
| Costume & Make-Up | Turid Follvik | Key Makeup Artist |
| Costume & Make-Up | Muriel Baurens | Key Makeup Artist |
| Costume & Make-Up | Frédéric Lainé | Special Effects Makeup Artist |
| Visual Effects | Thomas Duval | VFX Supervisor |
| Sound | Pierre Excoffier | Sound |
| Production | Dieter Meyer | Associate Producer |
| Sound | Jérôme Lévy | Foley |
| Sound | Olivier Marlangeon | Foley |
| Sound | Jérôme Wiciak | Sound |
| Sound | Mourad Louanchi | Foley Editor |
| Crew | Philippe Guégan | Stunt Coordinator |
| Production | Roland Pellegrino | Associate Producer |
| Production | Thomas Langmann | Associate Producer |
| Sound | Vincent Guillon | Sound |
| Production | Pierre Grunstein | Executive Producer |
| Sound | Gildas Mercier | Sound Editor |
| Visual Effects | Pierre-Alain Bloch | Animation |
| Writing | Albert Uderzo | Author |
| Sound | Philippe Chany | Original Music Composer |
| Production | Alain Chabat | Co-Producer |
| Editing | Stéphane Pereira | Editor |
| Camera | Laurent Dailland | Director of Photography |
| Costume & Make-Up | Philippe Guillotel | Costume Design |
