In his first film El Santo was still referred to as ‘El Enmascarado’. Rendered compliant by a scientist and his gangsters via a serum and mysterious rays, he is forced for the opening act to be a henchman for the evil forces who want to take over the world. The film has great historic value, due also to its impressive exterior shots of pre-revolutionary Cuba 1959.
Unfortunately the movie Santo vs. Evil Brain is not yet available on Disney Plus.
| Production | Enrique Zambrano | Producer |
| Sound | Salvador Espinosa | Music |
| Art | Carlos Nájera | Art Direction |
| Directing | Joselito Rodríguez | Director |
| Writing | Fernando Osés | Writer |
| Writing | Enrique Zambrano | Writer |
| Production | Jesús Alvariño | Co-Producer |
| Production | Jorge García Besné | Co-Producer |
| Production | Carlos Garduño G. | Co-Producer |
| Crew | Carlos Nájera | Cinematography |
| Editing | Jesús Echeverria | Editor |
| Costume & Make-Up | Elena Perez | Costume Design |
| Costume & Make-Up | Israel Fernández | Makeup Artist |
| Production | Oscar Dulzaides | Production Manager |
| Camera | Minervino Rojas | Camera Operator |
