Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of human corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device they have.
Unfortunately the movie Anaconda 3: Offspring is not yet available on Disney Plus.
| Directing | Don E. FauntLeRoy | Director |
| Writing | Nicholas Davidoff | Writer |
| Writing | David C. Olson | Writer |
| Costume & Make-Up | Allen Payne | Makeup Artist |
| Sound | Mark Hensley | Sound Re-Recording Mixer |
| Visual Effects | P.J. Foley | Visual Effects Producer |
| Sound | Trip Brock | Supervising Sound Editor |
| Sound | Nicolae Radu | Sound Mixer |
| Directing | Maria Nita | Second Assistant Director |
| Camera | Pãtru Pãunescu | Camera Operator |
| Production | Adrian Conerth | Unit Production Manager |
| Sound | Kyle Tilbury | Sound Re-Recording Mixer |
| Visual Effects | David Van Woert | Visual Effects Producer |
| Camera | Gabriel Kosuth | "A" Camera Operator |
| Directing | Cornelia Stefan | Script Supervisor |
| Directing | G. Peter King | Second Unit Director |
| Crew | Mircea Frenkel | Special Effects Technician |
| Visual Effects | Gretchen McNelis | Visual Effects |
| Visual Effects | Adam Clark | Visual Effects |
| Visual Effects | James Allan May | VFX Artist |
| Crew | Lucian Iordache | Special Effects |
| Costume & Make-Up | Allen Payne | Hairstylist |
| Camera | Toni Cartu | Camera Operator |
| Camera | Merav Maroody | Still Photographer |
| Costume & Make-Up | Mihaela David | Costume Supervisor |
| Art | Viorel Ghenea | Property Master |
| Production | Oana Topliceanu | Production Coordinator |
| Production | Adrian Conerth | Production Manager |
| Sound | Steven Avila | Sound Designer |
| Visual Effects | Adam Clark | Visual Effects Supervisor |
| Costume & Make-Up | Daniela Bușoiu | Key Makeup Artist |
| Costume & Make-Up | Adelina Handuri | Hairstylist |
| Crew | Gabi Burlacu | Stunts |
| Production | Jeff Gerrard | Casting |
| Crew | Ionel Popa | Special Effects |
| Production | Cristian Bostanescu | Executive In Charge Of Production |
| Production | Floriela Grapini | Casting |
| Crew | Vlad Iacob | Stunts |
| Lighting | Calin Catalin | Gaffer |
| Crew | Vasile Albineț | Stunt Coordinator |
| Crew | Valeriu Tomescu | Stunt Double |
| Crew | Razvan Gheorghiu | Stunts |
| Costume & Make-Up | Letitia Ghenea | Key Hair Stylist |
| Costume & Make-Up | Ionel Popa | Makeup Designer |
| Crew | G. Peter King | Stunt Coordinator |
| Crew | Mihai Iliescu | Stunts |
| Production | Alison Semenza | Producer |
| Production | Bryan S. Sexton | Co-Producer |
| Art | Vlad Roseanu | Art Direction |
| Costume & Make-Up | Ana Maria Cucu | Costume Design |
| Production | Vlad Păunescu | Co-Producer |
| Sound | Peter Meisner | Original Music Composer |
| Art | Șerban Porupcă | Production Design |
| Production | Benjamin Sacks | Line Producer |
| Camera | Don E. FauntLeRoy | Director of Photography |
| Art | Gina Calin | Set Decoration |
| Editing | Scott Conrad | Editor |
