When a wandering mercenary named Hogan rescues a nun called Sister Sara from the unwanted attentions of a band of rogues on the Mexican plains, he has no idea what he has let himself in for. Their chance encounter results in the blowing up of a train and a French garrison, as well as igniting a spark between them that survives a shocking discovery.
Unfortunately the movie Two Mules for Sister Sara is not yet available on Disney Plus.
| Directing | Don Siegel | Director |
| Writing | Albert Maltz | Screenplay |
| Production | Carroll Case | Producer |
| Production | Martin Rackin | Producer |
| Sound | Ennio Morricone | Original Music Composer |
| Camera | Gabriel Figueroa | Director of Photography |
| Editing | Robert F. Shugrue | Editor |
| Costume & Make-Up | Evelina Casas | Hairstylist |
| Crew | Buddy Van Horn | Stunt Coordinator |
| Crew | Leon Charles | Dialogue Coach |
| Sound | Stanley Wilson | Music Supervisor |
| Sound | Waldon O. Watson | Sound |
| Sound | Ronald Pierce | Sound |
| Sound | Jesús González Gancy | Sound |
| Costume & Make-Up | Frank Westmore | Makeup Artist |
| Costume & Make-Up | Margarita Ortega | Makeup Artist |
| Costume & Make-Up | Helen Colvig | Costume Design |
| Costume & Make-Up | Carlos Chávez | Costume Design |
| Production | William Davidson | Unit Production Manager |
| Production | Alfonso Sánchez Tello | Unit Production Manager |
| Directing | Joseph C. Cavalier | Second Unit Director |
| Directing | René Cardona | Second Unit Director |
| Editing | Juan José Marino | Editor |
| Crew | Frank Brendel | Special Effects |
| Crew | León Ortega | Special Effects |
| Directing | Joseph C. Cavalier | Assistant Director |
| Directing | Manuel Muñoz 'Torito' | Assistant Director |
| Art | José Rodríguez Granada | Art Direction |
| Art | Pablo Galván | Set Decoration |
| Writing | Budd Boetticher | Story |
| Camera | Gabriel Torres | Second Unit Director of Photography |
